This paper investigated the relationship between emotional intelligence and the mental health of medicine and surgery students in Ambrose Alli University, Ekpoma. The correlational design using the survey method was adopted in the study. The population of the work covered all the 1,244 medical undergraduate students in Ambrose Alli University, Ekpoma in the 2018/2019 session. A sample of two hundred students from the Department of Medicine and Surgery was drawn from the population. The purposive random sampling technique was used to draw 100 male and 100 female students in the Department.Two instruments were used for the collection of data. The test-retest method was used to determine the reliability of the instrument. The Pearson product moment correlation analysis was used to test the hypotheses at 0.05 level of significance. The levels of emotional intelligence and mental health of Medicine and Surgery students of Ambrose Alli University, Ekpoma were low (X ̅ of 2.45 and 2.46 ≤ 2.50). The result showed that there is a relationship between the emotional intelligence and the mental health of Medicine and Surgery students (male and female) of Ambrose Alli University, Ekpoma. It was recommended thatbalanced combination of emotional and cognitive mind training among undergraduates should be encouraged by the University Management and educators to facilitate the early identification, recognition and development of learners’ emotional skills which in turn could help promote their mental health.