Background: Edentulous patients rely on complete denture prostheses to restore oral function and esthetics. However, the maintenance of these prostheses is crucial for their longevity and the patient's overall oral health. Aim and objectives: The purpose of this study was to assess the perception of edentulous patients towards the maintenance of complete denture prostheses. Methodology: A survey was conducted among 200 edentulous patients who were wearing complete denture prostheses. The survey consisted of questions related to the maintenance of dentures and the importance of oral hygiene. Results: The majority of patients reported that they clean their dentures daily and soak them in a cleaning solution overnight. However, a significant number of patients had misconceptions about the proper maintenance of dentures. A considerable percentage of patients reported using toothpaste to clean their dentures, which can lead to the abrasion of denture material. Moreover, some patients do not remove their dentures at night, leading to the accumulation of plaque and oral bacteria. Conclusions: The study highlights the need for patient education regarding the proper care of complete denture prostheses. Dental professionals should provide edentulous patients with information about the proper maintenance of complete denture prostheses and the importance of oral hygiene in maintaining the health of the oral cavity. This study provides insight into the perceptions of edentulous patients towards the maintenance of complete denture prostheses, which can aid in the development of educational materials and interventions to improve patient education.