Pain, Anti-inflammatory, Cyclooxygenase enzymes, Ibuprofen, Piroxicam. Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly prescribed pain medications. It is a highly effective drug class for pain and inflammation. The analgesic and anti-inflammatory properties act by inhibiting two recognized isoenzymes of prostaglandin G/H synthase also known as cycloxygenase (COX), which are COX 1 and COX 2. NSAIDs are known for multiple adverse effects including gastrointestinal bleeding, cardiovascular side effects and induced nephrotoxicity etc. Therefore, we reviewed the pharmacodynamics and pharmacokinetics, use, adverse effects and drug interaction of NSAIDs.